Heparin-induced Thrombocytopenia Type II after Free Flap Operation
백지웅, 박중현, 차인호, 김형준,
소속 상세정보
백지웅 ( Baek Ji-Woong ) - Yonsei University College of Dentistry Department of Oral and Maxillofacial Surgery
박중현 ( Park Jung-Hyun ) - Yonsei University College of Dentistry Department of Oral and Maxillofacial Surgery
차인호 ( Cha In-Ho ) - Yonsei University College of Dentistry Department of Oral and Maxillofacial Surgery
김형준 ( Kim Hyung-Jun ) - Yonsei University College of Dentistry Department of Oral and Maxillofacial Surgery
KMID : 1036320130350060408
Abstract
After radical excision of a tumor in the maxillofacial area, functional and esthetic reconstruction is needed, including flap surgery. Among the many etiologies of flap failure, venous thrombosis is one of the most frequent. Heparin is used routinely in the effort to avoid development of venous thrombosis. In rare cases, heparin-induced thrombocytopenia (HIT) type II occurs due to exposure to heparin. Heparin attached to platelet factor 4 forms a PF4/heparin-immunoglobulin G immune complex on platelet surfaces. This complex activates platelets, which leads to multiple coagulation in venous and arterial blood. We report here on a rare occurrence of HIT type II following fibula free flap surgery.
키워드
HIT type II;Heparin-induced thrombocytopenia;Free tissue flaps;Heparin
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